Tearful Christina Applegate Mourns Death of Dad Robert Applegate

Rather, the As Luck Would Have It actress relied on life experience and “the universe” to pave her own way—even amid her yearslong battle with multiple sclerosis (MS), an auto-immune disease that, according to the Mayo Clinic, affects communication between the brain and the rest of the body.

“For three years, since I was diagnosed, I’ve been in the hospital upwards of 30 times from throwing up and diarrhea and pain,” Christina said on her podcast last month. “That is unimaginable, OK? They’ve done every test known to man on me, put so much radiation into my body from CT scans to everything else.”

And back in November, the Dead to Me star opened up about just how severe and excruciating the pain she experiences can get.

“Everybody has different ways of it showing up,” Christina said to Jamie-Lynn, who also lives with MS, at the time. “I lay in bed screaming. Like, the sharp pains, the ache, the squeezing.”

For more about Christina’s journey with MS, keep reading.